Nootropics

A family of supplements with unexpected properties

 
Although interest in them began with their possible role in the treatment of neurological diseases and disorders such as Alzheimer's, nootropics have found a small place in the research of performance in athletes. It is a category of supplements that are attributed a variety of properties that improve cognitive functions such as memory or the level of alertness and attention.
 
It is relevant to note that one of the molecules present in high concentration in nervous tissue is choline. For this reason, some of the most researched nootropics are used for their ability to raise choline levels in the brain: cholinergics. These supplements could improve cognitive functions, directly, by their actions on neurotransmitters, or indirectly, by their influence on hormones, which they will modulate cognitive mechanisms. Most commonly used in pre-workout mix recipes, Alpha-GPC and Huperzine-A.
 
Alpha-GPC
Alpha-GPC (glycerophosphocholine) is one such ingredient, which of all forms of choline provides the highest purity by weight, in addition to playing a role in cell membrane repair.
Cognitive ability and mood. Coupled with caffeine, it is known to increase attention span and response time. It would also increase the concentration of serotonin and dopamine in the brain.
Performance and muscle growth. In addition to the effects on concentration and focus, Alpha-GPC would allow an athlete to generate over 10% more power when consumed 45 minutes before training. Also, although the growth hormone is seen to rise naturally after a sustained physical effort, the consumption of Alpha-GPC would increase this increase a notch.
 
Huperzine-A
Extracted from a plant, Huperzine-A is also part of the cholinergic family. Its mode of action, indirect, increases the levels of choline by inhibiting an enzyme which degrades it. This ingredient would also have neuroprotective properties against certain oxidative molecules.
 
Typically incorporated into pre-workout blends, nootropics are great additions to engage focus with the uplifting nature of things like caffeine and theacrine. If the focus is well directed, we can bet on better muscle recruitment and a greater determination to push the '' rep '' more!
 
 
REFERENCES
1. Ziegenfuss, T., Landis, J. & Hofheins, J. Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance
 
exercise. J Int Soc Sports Nutr5, P15 (2008). https://doi.org/10.1186/1550-2783-5-S1-P15
 
 
 
4. Tayebati SK, et al.Modulation of monoaminergic transporters by choline-containing phospholipids in rat brain. CNS Neurol Disord Drug Targets. (2013)
 
5. Li YX, et al.Pharmacokinetics of huperzine A following oral administration to human volunteers. Eur J Drug Metab Pharmacokinet. (2007)
 
 
7. Yaoita Y, Danbara K, Kikuchi M.Two new aromatic compounds from Hericium erinaceum (BULL .: FR.) PERS (1). Chem Pharm Bull (Tokyo). (2005)
 
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